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how to aids virus attack the cell ?
By world2day

hiv virus


Tags: aids, biología, ciencia, hiv, infection, medicina, person..., prevenir, replicació, replicación, replication, sida, subtitulado, usmp, vih, virus, الايدز, فيروس
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HIV Replication 3D Medical Animation
By drrufusrajadurai

It is a very excellent animation which explains the hiv replication very clearly.
For free download of this video please visit my webpage
http://rufusrajadurai.wetpaint.com/
And other 3D animation videos visit
http://rufusrajadurai.wetpaint.com/pa...
Regards,
Dr.Rufus

The Lyrics of this video is here

Targeting HIV replication

The replication of HIV 1 is a multi-stage process.

Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs.

Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte.

Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4.

These receptors interact with protein-complexes, which are embedded in the viral envelope.

These complexes are composed of two glycoproteins:

an extracellular gp 120 and
a transmembrane gp 41

When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment.

It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120.

This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane.

Gp 41 then folds back on itself.

This draws the virus towards the cell and facilitates the fusion of their membranes.

The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes:

Integrase, Protease and Reverse Transcriptase.

Reverse Transcriptase begins the reverse transcription of viral RNA.

It has two catalytic domains:

The Ribonuclease-H active site

And the polymerase active site

Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA.

The polymerase then completes the remaining DNA-strand to form a DNA -- double helix.

Now Integrase goes into action.

It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends.

Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome.

The host cell genome now contains the genetic information of HIV.

Activation of the cell induces transcription of proviral DNA into messenger RNA.

The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised.

Some of them have to be processed by the viral protease.

Protease cleaves longer proteins into smaller core proteins.

This step is crucial to create an infectious virus.

Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid.

This immature particle leaves the cell acquiring a new envelope of host and viral proteins.

The virus matures and becomes ready to infect other cells.

HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression.

Drugs which interfere with the key steps of viral replication can stop this fatal process.

Entry into the host cell can be blocked by fusion inhibitors for example.

Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens.

The action of Integrase can be blocked.

Protease inhibitors are also part of standard antiretroviral therapy.

Each blocked step in viral replication is a step towards better control of HIV disease.


Script, Storyboard, Art Direction by: Frank Schauder, MD
Animation: MACKEVISION
Publicity: Dr.Rufus Rajadurai.MD.,D.DENS.,


Tags: 3d, aids, animation, ccr5, cd4, cxcr4, dr, hiv, medical, rajadurai, replication, rufus, virus
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Re: DNA Replication Process
By monty2222002

Video Cam Direct Upload


Tags: dna, encode, enzine, fragments, helicase, ligase, okazaki, polymerase, primase, primer, replication, rna, strand
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DNA Replication Process
By FreeScienceLectures

http://www.FreeScienceLectures.com

We travel inside nucleus to see how the DNA replicates.

When DNA replicates its strands are separated by enzine helicase.
Single-stranded DNA binding proteines keep the strands from (...?).
One DNA strand encodes the leading strand using DNA Polymerase III.

Just watch to see what is going on.

---
It's Never too Late to Study:
http://www.FreeScienceLectures.com
---
Notice: This video is copyright by its respectful owners.
The website address on the video does not mean anything.
---


Tags: dna, encode, enzine, fragments, helicase, ligase, okazaki, polymerase, primase, primer, replication, rna, strand
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JAPANESE WATER POWERED CAR!!
By raviwfc

As per the claims it runs only on a 300W "Water Energy System (WES)" where WATER is the only FUEL.


The basic power generation mechanism of the new system is similar to that of a normal fuel cell, which uses hydrogen as a fuel. According to Genepax, the main feature of the new system is that it uses the company's membrane electrode assembly (MEA), which contains a material capable of breaking down water into hydrogen and oxygen through a chemical reaction.


A Japanese venture company, Genepax, has unveiled a car on that runs on water. All it requires is a litre of water. In fact, any kind of water to be exact, whether its river, rain, sea water, or even Japanese tea. Its an electric powered car that runs solely on hydrogen dioxide.
"The main characteristic of this car is that no external input is needed. The car will continue to run as long as you have a bottle of water inside for you to add from time to time," said Kiyoshi Hirasawa, Chief Executive Officer of Genepax, after he proudly announced the company's invention.
Once water is poured into the water tank at the back of the car, the newly invented energy generator takes out the hydrogen from the water, releases electrons and finally generates electrical power.
"We highly recommend our system since it does not require you to build up an infrastructure to recharge your batteries, which is usually the case for most electric cars," said Hirasawa, who is hoping to advertise the car in time for the upcoming G8 Summit in Hokkaido, Japan.
According to the company, 1 liter of water keeps the car running for about an hour with a speed of 80 kilometers or 50 miles an hour. The company has applied for a patent and is hoping to collaborate with Japanese automobile manufacturers to mass manufacture their invention in the very near future. As fuel prices continue rising and people look for greener alternatives, companies globally are trying to come up with alternatives.

Details:

http://www.genepax.co.jp/en/

http://www.overunity.com/index.php?PH...,4929.0.html

http://techon.nikkeibp.co.jp/english/...


Tags: car, cell, dave, engine, fuel, hydrogen, hydroxy, ic, joe, joe's, lawton, meyer, raju, ravi, ravzz, replication, stan, stanley, water, wfc
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HIV VIRUS REPLICATION 3D
By carlitosusa1982

Description of the process how the HIV virus penetrated to our CD4 cells.


Tags: 3d, aids, hiv, replication, sida, virus
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Replicación del ADN con AUDIO latino
By gabyigl

Replicación del ADN (Horquilla con AUDIO LATINO)
Traducido al castellano por Gabriela Iglesias. Audio y música por Julio Amín.


Tags: adn, audio, castellano, del, en, replicación, replication
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The Origin of Life - Abiogenesis - Dr. Jack Szostak
By cdk007

This has been CONFIRMED in Dr. Jack Szostak's LAB. 2009 Nobel Laurette in medicine for his work on telomerase.

It's been 55 years since the Miller-Urey Experiment, and science has made enormous progress on solving the origin of life. This video summarizes one of the best leading models. Yes there are others. Science may never know exactly how life DID start, but we will know many ways how life COULD start. Don't be fooled by creationist arguments as even a minimal understanding of biology and chemistry is enough to realize they have no clue what they are talking about.

Note on how competition works. Water will flow across a membrane to try to equalize the ion concentration. If there is a lot of polymer in a vesicle it will be surrounded by many ions, thus causing water to flow into the vesicle, increasing the internal pressure and stretching the membrane. Fatty acids are in equilibrium between the vesicle and solution. If 2 vesicles are near one another they will gradually swap fatty acids. If one membrane is under tension, the fatty acid "on rate" will be greater than the "off rate" (move to a lower energy state by relaxing the pressure). It will suck up fatty acids from solution. The other vesicle will still give them off, but they will disappear (sucked up by neighbor) and not return. Therefore, the vesicle with high internal pressure will grow and the neighbor will shrink.

To download this video go to:
http://www.mediafire.com/?yyd0eywkmhj

If you wish to translate this video you can download the PowerPoint file from:
http://www.mediafire.com/?jfijmimctnd

For more info check out:
http://exploringorigins.org

Think about it.


Tags: 2009, ben, cell, creation, design, evolution, expelled, generation, intelligent, jack, nobel, primordial, prize, replication, soup, spontaneous, stein, szostak
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Body Code
By WEHImovies

Body Code is a selection of biomedical animations that explore the human body at the microscopic and molecular scale. Body Code was designed for museum and art gallery exhibition, with the goal of reaching public audiences who do not usually seek out or are exposed to the details of scientific knowledge. Since inception in 2003, these animations have exhibited in over 30 museums and art galleries around the world, including the Museum of Modern Art (USA), Museum of Design (Germany), Centre Pompidou (France), Shanghai Zendai Museum of Modern Art (China), Art Center Nabi (Korea) and the Australian Centre for the Moving Image (Australia).


Tags: anaemia, and, animation, base-pair, berry, biomedical, blood, bone, cell, chromatin, chromosome, codon, colony, dna, drew, eliza, factor, haemoglobin, hall, initiation, institute, machine, marrow, molecular, nucleosome, nucleus, packaging, polymerase, replication, ribosome, rna, sickle, stem, stimulating, transcription, transfer, trna, walter, wehi, wehi-tv, white
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