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The Day the Music Died: Buddy Holly, Ritchie Valens and The Big Bopper In this http://www.WatchMojo.com video, we learn more about the lives and deaths of rock and roll pioneers Buddy Holly, Ritchie Valens and J.P. "The Big Bopper" Richardson. Tags: airplanes, big bopper, bluegrass, buddy holly, chantilly lace, controversial titles, crashes, day the, death, donna, j.prichardson, la bamba, music, music died, parties, peggy sue, radio, ritchie valens, rock, rock n, rockabilly, roll, singers, songwriters, tragedy 7 Downloads - Last from: (Your Blog here!) |
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HIV Replication & Life Cycle 3D Medical Animation ORIGINAL VIDEO An excellent animation which explains the hiv replication very clearly. For free download of this video please visit my web page http://rufusrajadurai.wetpaint.com/ And other 3D animation videos visit http://rufusrajadurai.wetpaint.com/pa... Regards, Dr.Rufus The Lyrics of this video is here Targeting HIV replication The replication of HIV 1 is a multi-stage process. Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs. Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte. Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4. These receptors interact with protein-complexes, which are embedded in the viral envelope. These complexes are composed of two glycoproteins: an extracellular gp 120 and a transmembrane gp 41 When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment. It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120. This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane. Gp 41 then folds back on itself. This draws the virus towards the cell and facilitates the fusion of their membranes. The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes: Integrase, Protease and Reverse Transcriptase. Reverse Transcriptase begins the reverse transcription of viral RNA. It has two catalytic domains: The Ribonuclease-H active site And the polymerase active site Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA. The polymerase then completes the remaining DNA-strand to form a DNA -- double helix. Now Integrase goes into action. It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends. Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome. The host cell genome now contains the genetic information of HIV. Activation of the cell induces transcription of proviral DNA into messenger RNA. The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised. Some of them have to be processed by the viral protease. Protease cleaves longer proteins into smaller core proteins. This step is crucial to create an infectious virus. Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid. This immature particle leaves the cell acquiring a new envelope of host and viral proteins. The virus matures and becomes ready to infect other cells. HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression. Drugs which interfere with the key steps of viral replication can stop this fatal process. Entry into the host cell can be blocked by fusion inhibitors for example. Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens. The action of Integrase can be blocked. Protease inhibitors are also part of standard antiretroviral therapy. Each blocked step in viral replication is a step towards better control of HIV disease. Script, Storyboard, Art Direction by: Frank Schauder, MD Animation: MACKEVISION Publicity: Dr.Rufus Rajadurai.MD.,D.DENS., Tags: 3d, aids, animation, ccr5, cd4, cell, chromosome, controversial titles, cxcr4, death, dna, doctors, dr.rufus, education, genetic, helix, hiv, medical, medicine, nucleotide, nucleus, profession, rajadurai, replication, rna, rufus, students, viral, virus 13 Downloads - Last from: (Your Blog here!) |
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Possum Death Spree Fact: An ancient breed of bloodthirsty possums were responsible for the extinction of the dinosaurs. Fact: The Ice Age put these possums into deep hibernation. Fact: The possums have awoken, and they're very, very hungry. Watch the full feature at http://Possums.AtomFilms.com Tags: animals, blood, controversial titles, death, horror, kill, killing, movies, parody, possums, spoof, spree, tv 14 Downloads - Last from: (Your Blog here!) |
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Michael Jackson is NOT Dead! Michael Jackson is NOT dead! The King Of Pop has started the most elaborate, most daring, most unbelievable media stunt of all time! A brilliant plan to get back on top in one big swoop! A move only the mind of MJ could concieve! SUBSCRIBE to my channel! For more video's and updates of what I'm cooking up on the web visit www.renatovanbloemenhuis.tumblr.com Tags: arrest, attack, autopsie, autopsy, bad, beat, billy, cardiac, concerts, controversial titles, dead, death, doctors, family, heart, hoax, incredible, is, it, jacksons, jean, king of pop, london, media, michael jackson, mj, not, o2, o2arena, rip, thrillers 9 Downloads - Last from: (Your Blog here!) |
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Eaten Alive (1977) "Meet the maniac, and his friend." From Tobe Hooper, the director of "The Texas Chain Saw Massacre", get ready for "EATEN ALIVE"! The New Horror Classic! Based on the Legend of Joe Ball. Tags: 1977, 70's, aka, alive, alligators, carolyn, death, drive-in, eaten, exploitation, ferrer, film, horror, hotels, jones, killers, mardi, mel, motel, movie, psycho, robert englund, rustam, sickle, slaughter, starlight, stuart, tobe hooper, trailers, trap 12 Downloads - Last from: (Your Blog here!) |
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HIV Replication & Life Cycle 3D Medical Animation ORIGINAL VIDEO An excellent animation which explains the hiv replication very clearly. For free download of this video please visit my web page http://rufusrajadurai.wetpaint.com/ And other 3D animation videos visit http://rufusrajadurai.wetpaint.com/pa... Regards, Dr.Rufus The Lyrics of this video is here Targeting HIV replication The replication of HIV 1 is a multi-stage process. Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs. Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte. Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4. These receptors interact with protein-complexes, which are embedded in the viral envelope. These complexes are composed of two glycoproteins: an extracellular gp 120 and a transmembrane gp 41 When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment. It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120. This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane. Gp 41 then folds back on itself. This draws the virus towards the cell and facilitates the fusion of their membranes. The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes: Integrase, Protease and Reverse Transcriptase. Reverse Transcriptase begins the reverse transcription of viral RNA. It has two catalytic domains: The Ribonuclease-H active site And the polymerase active site Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA. The polymerase then completes the remaining DNA-strand to form a DNA -- double helix. Now Integrase goes into action. It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends. Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome. The host cell genome now contains the genetic information of HIV. Activation of the cell induces transcription of proviral DNA into messenger RNA. The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised. Some of them have to be processed by the viral protease. Protease cleaves longer proteins into smaller core proteins. This step is crucial to create an infectious virus. Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid. This immature particle leaves the cell acquiring a new envelope of host and viral proteins. The virus matures and becomes ready to infect other cells. HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression. Drugs which interfere with the key steps of viral replication can stop this fatal process. Entry into the host cell can be blocked by fusion inhibitors for example. Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens. The action of Integrase can be blocked. Protease inhibitors are also part of standard antiretroviral therapy. Each blocked step in viral replication is a step towards better control of HIV disease. Script, Storyboard, Art Direction by: Frank Schauder, MD Animation: MACKEVISION Publicity: Dr.Rufus Rajadurai.MD.,D.DENS., Tags: 3d, aids, animation, ccr5, cd4, cell, chromosome, controversial titles, cxcr4, death, dna, doctors, dr.rufus, education, genetic, helix, hiv, medical, medicine, nucleotide, nucleus, profession, rajadurai, replication, rna, rufus, students, viral, virus 12 Downloads - Last from: (Your Blog here!) |
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Pakistan Flood Death Toll over 800,emergency http://linkbee.com/F4NH6 all right reserved to RT NOWSHERA, Pakistan — The death toll in the massive flooding in Pakistan surged past 800 as floodwaters receded Saturday in the hard-hit northwest. Tags: 800, controversial titles, death, flood, floodwaters, pakistan, rescuers 11 Downloads - Last from: (Your Blog here!) |
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