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Sexy Legs

Two girls sitting on the step just showing off ther lovely legs.


Tags: controversial titles, girls, hot, legs, sexy
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HIV Replication & Life Cycle 3D Medical Animation

ORIGINAL VIDEO An excellent animation which explains the hiv replication very clearly. For free download of this video please visit my web page http://rufusrajadurai.wetpaint.com/ And other 3D animation videos visit http://rufusrajadurai.wetpaint.com/pa... Regards, Dr.Rufus The Lyrics of this video is here Targeting HIV replication The replication of HIV 1 is a multi-stage process. Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs. Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte. Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4. These receptors interact with protein-complexes, which are embedded in the viral envelope. These complexes are composed of two glycoproteins: an extracellular gp 120 and a transmembrane gp 41 When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment. It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120. This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane. Gp 41 then folds back on itself. This draws the virus towards the cell and facilitates the fusion of their membranes. The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes: Integrase, Protease and Reverse Transcriptase. Reverse Transcriptase begins the reverse transcription of viral RNA. It has two catalytic domains: The Ribonuclease-H active site And the polymerase active site Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA. The polymerase then completes the remaining DNA-strand to form a DNA -- double helix. Now Integrase goes into action. It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends. Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome. The host cell genome now contains the genetic information of HIV. Activation of the cell induces transcription of proviral DNA into messenger RNA. The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised. Some of them have to be processed by the viral protease. Protease cleaves longer proteins into smaller core proteins. This step is crucial to create an infectious virus. Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid. This immature particle leaves the cell acquiring a new envelope of host and viral proteins. The virus matures and becomes ready to infect other cells. HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression. Drugs which interfere with the key steps of viral replication can stop this fatal process. Entry into the host cell can be blocked by fusion inhibitors for example. Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens. The action of Integrase can be blocked. Protease inhibitors are also part of standard antiretroviral therapy. Each blocked step in viral replication is a step towards better control of HIV disease. Script, Storyboard, Art Direction by: Frank Schauder, MD Animation: MACKEVISION Publicity: Dr.Rufus Rajadurai.MD.,D.DENS.,


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Bikini-Clad Ashley Olsen Makes a Splash in Hawaii

Ashley Olsen let her personality shine through on the beach in Hawaii while she takes a dip wearing just a tiny bikini.


Tags: ashley olsen, bikini, controversial titles, dip, hawaii, oceans, splash
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Possum Death Spree

Fact: An ancient breed of bloodthirsty possums were responsible for the extinction of the dinosaurs. Fact: The Ice Age put these possums into deep hibernation. Fact: The possums have awoken, and they're very, very hungry. Watch the full feature at http://Possums.AtomFilms.com


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Naked and Funny. Help Me With My Computer 2210.

Help Me With My Computer


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Stupid Girls

Are all the girls same??? :)


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Yukta Mukhey Boob Grab (Memsaab)

Finally a lucky guy grab the boob of a sexiest girl... really lucky :P


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Derailed (2005): Robbed and Raped

The clip Robbed and Raped from Derailed (2005) Always... ...chain your door in a place like this. But, hey, thanks for the invite. I'll give you all my money. "No sound" means you shut the fuck up. Please don't hurt him. You get that? Give me your fuckin' wallets now. Come on, give me your wallet. Come on, come on. This doesn't look like her... ...Charlie. Hmm. That stupid fuck doesn't look like you, neither. Lucinda. You two fuckin' around, huh? Slummin' it, ain't ya? You're fuckin' slummin' it, you piece of shit. Isn't that exciting? Please, just take the money. Chuck, I already took your money. You see this? This was your money, and I took it. Now it's mine. I promise we won't go to the police. I know you won't 'cause you look like a nice guy. Ain't you a nice guy? You look nice to me. She looks kinda nice. Are you nice? Lucinda. Oh! No! Let her go, please. Come on, come on. Please. How can I let her go, such a fine piece of ass like that? Look at that. Me and fuckin' Lucinda, we gotta do a lot of things together. All kinds of shit. Oh, man. I could make you scream, you know? Is she better than your wife at home? Ha. Look at that.


Tags: anyclip, controversial titles, derailed (2005 film), robbed and raped
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Along Came Polly (2004): Having Sex

The clip having sex from Along Came Polly (2004) with Jennifer Aniston, Ben Stiller I just have to go pee. Okay. Just kidding! Oh! Funny. Do it, do it Do it again Let's do it again I wanna do it again Sometimes the rain Hey. Hi. Like you and me, baby Gettin' down with the sounds around Oh, the smell of the morning flower As we pass away the hours I wanna do it again Do it again Do it Ow! Did you just spank me? No! I don't... No. Mm-mmm. Are you sure? 'Cause it felt like you just swatted me. No, no, you... I have a little crick in my wrist. You just felt that little... I was just... Do you hear that? Really? Yeah. You hear that? Well, I got it out. Yeah. Yeah. Oh, wow. This is incredible. Oh, man. Oh, God. Oh, yeah. Oh, no! No, no. You can't be done yet.


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Meet Joe Black (1998): Pool Room Sex Scene Part 4

The clip pool room sex scene Part 4 from Meet Joe Black (1998) with Claire Forlani I loved making love to you.


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Dude Boobs with Will Ferrell and Zach Galifianakis

Just because Matt Zaller has dude boobs doesn't mean he deserves any less respect. C'mon, Zach Galifianakis - pull it together. The Campaign stars Will Ferrell and Zach Galifianakis. In theaters August 10.


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Reese Witherspoon Wears a Sexy Revealing Top for Premiere

Actress Reese Witherspoon stunned the paparazzi when she made an appearance for the premiere of her film “This Means War”. The sexy actress wore a very low-cut albeit sexy top that wowed the photographers as she posed for them. Take a look.


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Hot Sexy Glamour Model Kalen Brest - Arizona Boudoir

http://www.MandarichModels.com Glamour boudoir model Kalen Brest shoots with Mandarich Models. http://www.MandarichModels.com Distributed by Tubemogul.


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Xxx-wild Lovers Having Crazy Sex in Public Cocktail Party

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Actress Cameron Diaz Having Sex in Bathroom

Watch Actress Cameron Diaz having sex in bathroom.For more FREE celeb vdo visit-http://www.celebvdo.com


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Watch Very Hot & Sexy Movie "Vanakanya" Full Of Sexy Scene

Watch Very Hot & Sexy Babe As "Vanakanya" In Movie "Vankanya"


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The Day the Music Died: Buddy Holly, Ritchie Valens and The Big Bopper

In this http://www.WatchMojo.com video, we learn more about the lives and deaths of rock and roll pioneers Buddy Holly, Ritchie Valens and J.P. "The Big Bopper" Richardson.


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Megan Fox Hot Sexy Clip (slideshow)

Megan Fox best pictures gathered together


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Sexy Nude & Hottest Bikini Scene from a Movie

don't know exactly, but funny


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Hot Sexy Glamour Model Kalen Brest - Arizona Boudoir

http://www.MandarichModels.com Glamour boudoir model Kalen Brest shoots with Mandarich Models. http://www.MandarichModels.com Distributed by Tubemogul.


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